Compositions, systems, and methods of treating conditions such as vascularcalcification conditions are disclosed. Arepresentative method includes administering to an individual in need oftreatment an effective amount of at least one effector agent.Another method includes prophylactically treating vascular calcification orvascular calcification-related conditions by administeringto an individual in need of treatment an effective amount of at least oneeffector agent. Still another method includes treating vascularcalcification by administering an effective amount of at least one effectoragent to an individual in need of treatment via hemodialysis.
