CHEN, YI MING,陈宜民,陳宜民,HUNG, JUNG HSIEN,洪荣贤,洪榮賢,FANG, CHENG CHIEH,方诚杰,方誠傑
申请号：
TW106116521
公开号：
TW201842184A
申请日:
2017.05.18
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present invention discloses Glycine N-methyltransferase (GNMT) mutant genes for preventing the interference of miRNA hsa-miR-224 and to prevent or treat liver diseases, the GNMT mutant genes includes gene sequences being one selected from a group consisting of SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14 and SEQ ID NO: 15. A recombination vector including an adeno-associated viral vector (AAV) and the GNMT mutant genes prevents and treats liver cancer and the worsening of liver diseases, and protects liver functions.本發明為一種用於防止與癌症有關的微小RNA hsa-miR-224干擾進而預防或治療肝臟疾病的甘胺酸氮甲基轉化酶(GNMT)突變基因,包括選自由SEQ ID NO:3、SEQ ID NO:4、SEQ ID NO:5、SEQ ID NO:6、SEQ ID NO:7、SEQ ID NO:8、SEQ ID NO:9、SEQ ID NO:10、SEQ ID NO:11、SEQ ID NO:12、SEQ ID NO:13、SEQ ID NO:14及SEQ ID NO:15所組成的群組至少其中之一的基因序列。利用腺相關病毒載體攜帶本發明的甘胺酸氮甲基轉化酶(GNMT)突變基因所形成的重組載體,具有改善及治療慢性肝臟疾病的惡化與肝癌及保護肝臟功能。
