NOUVEL ANTICORPS BISPECIFIQUE SE LIANT AU TLR2 HUMAIN ET AU TLR4 HUMAIN

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专利权人:

ASTELLAS PHARMA INC.

发明人:

TAKEUCHI, SATOSHI,SATO, MASAHITO,SUZUKI, JOTAROU,SOGA, SHINJI,TAKASAKI, JUN,AOYAMA, KOJI,OKUYAMA, CHIE

申请号：

CA2941014

公开号：

CA2941014A1

申请日:

2015.02.27

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

[Problem] To provide a bispecific antibody for the prevention or treatment of immune inflammatory diseases by acting on both human TLR2 and human TLR4, and inhibiting a human TLR2- and human TLR4-mediated immune inflammatory effect. [Solution] Provided is a bispecific antibody for human TLR2 and human TLR4, said antibody including: a heavy chain variable region of an anti-human TLR2 antibody comprising the amino acid sequence from amino acid number 1 to 120 of SEQ ID NO: 4； a light chain variable region of an anti-human TLR2 antibody comprising the amino acid sequence from amino acid number 1 to 113 of SEQ ID NO: 6； a heavy chain variable region of an anti-human TLR4 antibody comprising the amino acid sequence from amino acid number 491 to 609 of SEQ ID NO: 4； and a light chain variable region of an anti-human TLR4 antibody comprising the amino acid sequence from amino acid number 625 to 732 of SEQ ID NO: 4.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/