A cartridge system of a multi-ported drug delivery device with independently actuated collapsible reservoirs, for delivery of medicaments, which includes membranes placed between disk magnets that are housed within pump body inserts. The pump body inserts having flow channels and fluid openings are between two inlet/outlet members with communication control through active valves and dynamically stressed membranes. The inlet/outlet members of the cartridge system each having a fluid outlet component and fluid openings are securely engaged to two or more reservoirs containing fluid medicaments. The cartridge system driven by the pump driver system delivers an appropriate dosage of medicament for treatment prescribed.