A composition and method for alleviation of pain and inflammation which alleviates pain and inflammation from muscle strain, spasms, arthritis, and bursitis. The composition and method for alleviation of pain and inflammation generally includes a combination of lidocaine HCl, hydrocortisone acetate, menthol, glucosamine HCl, and a number of other ingredients. The composition described and claimed herein has been shown to alleviate pain and inflammation from injuries and conditions such as muscle strains, spasms, arthritis, and bursitis. The composition will preferably be incorporated into a topical cream which may be applied to the skin around the affected area to provide not only immediate relief from pain and inflammation, but also long-lasting relief which may last for days or even weeks.