SOARES DA SILVA, Patrício Manuel Vieira Araújo,BONIFÁCIO, Maria João Macedo da Silva
申请号：
DK13803292
公开号：
DK2919780T3
申请日:
2013.11.14
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group； R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl； X signifies CH2, oxygen atom or sulphur atom； n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2； and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof.
