FORMES POLYMORPHES DE SEL DE CHLORHYDRATE DE 3-(1-{3-[5-(1-METHYL-PIPERIDIN-4-YLMETHOXY)-PYRIMIDIN-2-YL]-BENZYL}-6-OXO-1,6-DIHYDRO-PYRIDAZIN-3-YL)-BENZONITRILE ET PROCEDES DE FABRICATION DESDITES FORMES
BECKER, AXEL,KUEHN, CLEMENS,SAAL, CHRISTOPH,SCHADT, OLIVER,DORSCH, DIETER,BOKEL, HEINZ-HERMANN,STIEBER, FRANK,DONINI, CHRISTINA
申请号：
CA2749012
公开号：
CA2749012C
申请日:
2009.12.04
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to hydrochloride solvates of3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)--pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile and crystalline modifications thereof.The present inven-tionfurther relates to processes of manufacturing these crystalline modificationsas well as their use in the treatment and/or pro-phylaxisof physiological and/or pathophysiological conditions, which are caused,mediated and/or propagated by the inhibition,regulation and/or modulation of signal transduction of kinases, in particularby the inhibition of tyrosine kinases, e.g. pathophysio-logicalconditions such as cancer.
