Provided herein is a method for identifying a genetic variantthat is associated with development of a condition of interest (e.g.,Alzheimers disease), and genetic variants so identified. Methods of treatmentwith an active agent (e.g., with a particular active agent and/or at anearlier age) is also provided, upon detecting a genetic variant describedherein. In some embodiments, the genetic variant is a deletion/insertionpolymorphism (DIP) of the TOMM40 gene. Kits for determining if a subjectis at increased risk of developing late onset Alzheimers disease is alsoprovided. Kits for determining if a subject is responsive to treatment for acondition of interest with an active agent are further provided.
