Dubensky Thomas W. Jr.,Leong Meredith Lai Ling,Pardoll Drew M.,Kim Young Jun
申请号：
NZ70239213
公开号：
NZ702392A
申请日:
2013.06.07
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
The present invention provides a combination therapy which relies on a small molecule immune stimulator - cyclic-di-nucleotide (CDN) - that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) formulated with allogeneic human tumor cell lines engineered to secrete high amounts of GM-CSF. This combination therapy can provide an ideal synergy of multiple tumor associated antigens, DC recruitment and proliferation, coupled with a potent DC activation stimulus.
