UNIVERSITY OF CONNECTICUT;MIGLIARESI, CLAUDIO;MOTTA, ANTONELLA
发明人:
DIBENEDETTO, ANTHONY T.,MIGLIARESI, CLAUDIO,MOTTA, ANTONELLA,HUANG, SAMUEL JIEN-SHEK
申请号：
CA2466001
公开号：
CA2466001C
申请日:
2002.10.25
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A bioactive material is made using fibroin solutions and suspensions that canbe used alone or as a composite with particles such as core/shell particles.The material is designed to support the constructions, repair, regeneration oraugmentation of bone and other tissues of the body. The solutions andsuspensions can be loaded with core/shell-type particles comprising inorganiccore materials that are coated with biodegradable polymers with an outercoating of a calcium phosphate precursor. The fibroin solutions, suspensions,and composites can be injected to fill cavities or to replace missing tissue.After injection, the materials can produce a scaffold capable of promotingtissue regeneration while degrading. The degradation of the particles, whenpresent, can generate additional porosity within the scaffold and releaseother compounds in a controlled manner to enhance growth and activation of thecells necessary for tissue repair. The ability to inject the fibroinsolutions, suspensions and composites can reduce the need for many types ofsurgical procedures that are used to replace or repair bone and other tissues.
