新穎癌症免疫治療抗體組合物农业专利-农业学术服务平台

发明人:: LI, CHIANG J.,李嘉强,李嘉強,UNNIRAMAN, SHYAM,乌尼拉曼　希亚姆,烏尼拉曼　希亞姆,BADER, HANNAH,巴德　汉娜,巴德　漢娜,JHA, MITHILESH,贾赫　米奇莱什,賈赫　米奇萊什

摘要：: The present invention provides novel compositions and methods related to or derived from anti-PD-L1 antibodies having ADCC and / or CDC activity. More specifically, the present invention discloses fully human antibodies that bind to PD-L1, PD-L1 binding antibody fragments and derivatives, and PD-L1 binding polypeptides containing these fragments.本發明提供了與具有ADCC和/或CDC活性的抗PD-L1抗體相關或來源於該抗體的新型組合物和方法。更具體地，本發明公開了結合PD-L1的全人源抗體、PD-L1結合抗體片段和衍生物以及包含這些片段的PD-L1結合多肽。