LA MOTTE MOHS ROSS,SHAH KALPANA,SMITH DOUGLAS H,JOHNSON LESILE S,MOORE PAUL A,BONVINI EZIO,KOENIG SCOTT
申请号：
IN201717044035
公开号：
IN201717044035A
申请日:
2017.12.07
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present invention is directed to the anti LAG 3 antibodies LAG 3 mAb 1 LAG 3 mAb 2 LAG 3 mAb 4 LAG 3 mAb 5 and LAG 3 mAb 6 and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG 3 binding molecules that comprise LAG 3 binding fragments of such anti LAG 3 antibodies immunocongugates and to bispecific molecules including diabodies BiTEs bispecific antibodies etc. that comprise (i) such LAG 3 binding fragments and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG 3 as well as methods of using molecules that bind LAG 3 for stimulating immune responses.
