CYCLIC TETRAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS

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专利权人:

NOVARTIS AG

发明人:

Karin BRINER,Brian Addison DECHRISTOPHER,Alec Nathanson FLYER,Andrei Alexandrovich GOLOSOV,Philipp GROSCHE,Eugene Yuejin LIU,Justin Yik Ching MAO,Lauren Gilchrist MONOVICH,Tajesh Jayprakash PATEL,Cari

申请号：

US16695843

公开号：

US20200164024A1

申请日:

2019.11.26

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I):or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/