Systems are disclosed which include processor-executable program instructions for receiving data regarding characteristics of a room in which one or more disinfection sources are arranged and determining, based on the received data, individual operating parameter/s for the one or more disinfection sources. Other systems are provided which include processor-executable program instructions for discerning, for each of a plurality of disinfection sources, a target location, region, object or surface within a room in which the disinfection sources are arranged. The systems further include program instructions for comparing the target locations/regions/objects/surfaces and executing corrective actions upon detecting two or more locations/objects/surfaces are within a predetermined distance of each other and/or upon detecting two or more regions overlap.