The present disclosure is generally directed to compositions that include antibodies,e.g., monoclonal, antibodies, antibody fragments,etc., that specifically bind a SIRPA polypeptide,e.g., a mammalian SIRPA or human SIRPA, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.本發明大體上關於包括特異性結合SIRPA多肽(例如：哺乳動物SIRPA或人類SIRPA)之抗體(例如：單株抗體、抗體片段，等等)的組合物，及此類組合物在預防、降低風險或治療有此需要之個體上的用途。
