METHODES DE TRAITEMENT DE L'EPUISEMENT DES LYMPHOCYTES T PAR L'INHIBITION OU LA MODULATION DE LA SIGNALISATION DE RECEPTEURS DE LYMPHOCYTES T

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专利权人:

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人:

LYNN, RACHEL,MACKALL, CRYSTAL,WEBER, EVAN,MALHOTRA, SANJAY

申请号：

CA3057505

公开号：

CA3057505A1

申请日:

2018.03.30

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Provided herein are compositions and methods for preventing or reversing T cell exhaustion. In particular, the present invention relates to methods of preventing or reversing T cell exhaustion by exposing T cells experiencing T cell exhaustion to particular tyrosine kinase inhibitors (e.g., dasatinib, ponatinib), or by expanding genetically engineered T cells in the presence of particular tyrosine kinase inhibitors (e.g., dasatinib, ponatinib).

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中国工程科技知识中心

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