A power injection catheter assembly includes a power injection catheter having an elongate tubular body. The elongate tubular body has a proximal end and a distal end and defines a power injection lumen. A manifold is attached at the proximal end of the elongate tubular body and defines a first power injection channel extending from a first power injection port of the manifold to the power injection lumen, and a second power injection channel extending from a second power injection port of the manifold to the power injection lumen. A first power injection extension tube has a proximal end defining a first power injection hub and a distal end attached to the manifold at the first power injection port. A second power injection extension tube has a proximal end defining a second power injection hub and a distal end attached to the manifold at the second power injection port.