Methods, systems, and devices are disclosed for administering one or more medications useful for facilitating diagnostic and/or surgical procedures within a patient. A guidewire is positioned intravascularly in a patient at a location of interest, the guidewire being free of any coating that includes adenosine. An intravascular component having a surface with a coating that includes a vasodilation agent is deployed over the guidewire. The vasodilation agent is released from the surface of the intravascular component, such as by eluting the vasodilation agent from the coating of the surface while the intravascular component is within the anatomical structure of the patient. The intravascular component is removed over the guidewire, and the guidewire is left at the location of interest after the intravascular component is removed, which can facilitate subsequent deployment of a different intravascular component over the guidewire.
