A system for utilizing diagnostics for informed vibrant constitutional guidance includes a diagnostic engine operating on at least a server and configured to receive a first training set including a plurality of first data entries, receive a second training set including a plurality of second data entries, receive at least a biological extraction from a user and generate a diagnostic output including at least a prognostic label and at least an ameliorative process label using the first training set, the second training set, and the at least a biological extraction. The system includes at least an advisory module operating on at least the server and configured to generate at least an advisory output as a function of the diagnostic output and transmit the at last an advisory output to at least an advisor client device.