This invention, non mineralization (non-mineralized) connective tissue and especially coating organization (the skin and the viscous substance, the cartilage and the tendon) is related to engineering. Subject of this invention, between 500,000g/mol and 2,000,000g/mol, desirably to have the weight average mol mass between 700,000g/mol and 900,000g/mol, 4 oshido residues:[(- 3) - DGlcNac (1-4) DGlcA (1-4) DGlcA (1-4) DGalNac (1-)]It is the collagen matrix which includes the salt of the polysaccharide or this polysaccharide which is characterized by the direct condition repetition oshido arrangement which is included.本発明は、非無機化(non-mineralized)結合組織、特に被覆組織(皮膚、粘性物質、軟骨、腱)の工学に関係する。本発明の主題は、500,000g/molと2,000,000g/molの間、好ましくは700,000g/molと900,000g/molの間の重量平均モル質量を有し、4オシド残基:[(-3)-DGlcNacβ(1-4)DGlcAβ(1-4)DGlcAβ(1-4)DGalNacα(1-)]を含む直鎖状反復オシド配列により特徴づけられる多糖、またはこの多糖の塩を含むコラーゲンマトリックスである。