Andreas Keller,Eckart Meese,Cord Friedrich Stähler,Andreas Kappel,Petra Leidinger,Christina Backes
申请号：
US14396827
公开号：
US10161004B2
申请日:
2013.04.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to methods for diagnosing multiple sclerosis with miRNA markers. Diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during a first neurological deficit possibly related to inflammatory demyelination. Towards the identification of biomarkers for diagnosis of MS, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified, which have previously not been related to MS according to the microRNA disease database. These miRNAs could potentially serve as future diagnostic biomarkers for MS and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS.
