present invention relates to novel compounds, and cancer and its pre-cancerous symptoms of prevention and / or treating, pain and heat treatment, the treatment of skin diseases, and immune-provides a pharmaceutical composition for the treatment of related diseases and / or cardiovascular disease. The compounds of the invention may also analgesic properties and anti-platelet properties have. The compounds of the invention may be provided in a suitable pharmaceutical dosage form suitable for pharmaceutical administration to animals, including mammals and humans. The compounds of the present invention compared to the conventional treatment, including a higher potency and / or fewer or less serious side effects, have improved efficacy and stability. The compounds of the present invention comprises a biologically active moiety or at least one part has been modified to have a carboxyl group, or (A). And the moiety A is preferably aliphatic, aromatic, or alkyl aryl group, preferably a non-steroidal anti-inflammatory drugs, or derives from NSAID. The moiety A is bound to the linker moiety (B) through a connecting atom selected from carboxylic and oxygen, nitrogen, and sulfur of the group A, between a carboxylic ester, amide, or thioester, groups A and B It forms a bond (X1). Moiety B is a single bond, an aliphatic group, a substituted benzene, or an alkylene chain substituted hydrocarbon, which in turn binds to the functional moieties Z, to facilitate the access of these compounds to the cells. The moiety Z are, for example, phosphorus-containing group, a nitrogen-containing group, or may comprise a folic acid residue본 발명은 신규 화합물, 및 암과 이의 전암성 증상의 예방 및/또는 치료, 통증 및 열의 치료, 피부 질환의 치료, 및 면역-관련 질환 및/또는 심혈관 질환의 치료를 위한 약학적 조성물을 제공한다. 본 발명의 화합물은 또한 진통제 특성 및 항-혈소판 특성을 갖는다. 본 발명의 화합물은 적합한 약학적 투약 형태로 적합한 약학적 투여량으로 포유동물 및 인간을 비롯한 동물에 제공될 수 있다. 본 발명의 화합물은 통상적인 치료에 비해, 더 높은 효력 및/또는 적거나 더 적은 심각한 부작용을 포함하는, 개선된 효능 및 안정성을 갖는다. 본 발명의 화합물은 적어도 하나의 카르복실기를 갖거나 갖도록 변형된 생물학적 활성 모이어티 또는 부분(A)를 포함한다
