INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
Tao LU,Lakshmi Milind PRABHU
申请号：
US16344644
公开号：
US20200062745A1
申请日:
2017.10.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are compounds of formulas (I), (II), (III), and (IV), which effectively inhibit protein arginine methyltransferase 5 (PRMT5). Also provided are methods of using the compounds, including a method of treating cancer, a method of inhibiting the activity of PRMT5 in a cell, and a method of treating a disease associated with increased activity of PRMT5.
