object of the present invention have a higher good moldability good granule formulation without cut using a water-cooled cutter to obtain, to satisfy the performances and required the lumen bypassing agents such as it is to provide a biologically active substance-containing composition that can. Biologically active substance-containing composition of the present invention, the melting point of aliphatic monocarboxylic acids of linear or branched, saturated or unsaturated having from 8 to 24 a and the carbon atoms at less than 50 (1a), the melting point and a linear or branched, saturated or unsaturated, with 8 to 24 a and carbon atom at 50 or more aliphatic monocarboxylic acid (1b), the calcium content and carbon atom in the 8 to 12% by weight, 12 to 24 linear or branched, saturated or unsaturated aliphatic calcium salt of a monocarboxylic acid and (2) and the protective substance 10 to 50% by weight containing, biologically active substances are dispersed in said protective substance having a containing a 50 to 90% by weight.本発明の目的は、水冷式カッターを用いて切断しなくても良好な顆粒製剤が得られるほどの良好な成形性を有し、且つルーメンバイパス製剤等に要求される性能を満足させることができる生物学的活性物質含有組成物を提供することである。本発明の生物学的活性物質含有組成物は、融点が50℃未満で且つ炭素原子を8~24を有する直鎖または分岐の飽和または不飽和の脂肪族モノカルボン酸(1a)と、融点が50℃以上で且つ炭素原子を8~24を有する直鎖または分岐の飽和または不飽和の脂肪族モノカルボン酸(1b)と、カルシウム含有量が8~12質量%で且つ炭素原子を12~24を有する直鎖または分岐の飽和または不飽和の脂肪族モノカルボン酸のカルシウム塩(2)とを含有する保護物質10~50質量%と、該保護物質中に分散してなる生物学的活性物質50~90質量%とを含有する。
