A fluorescence endoscopy video system (50) includes a multi-mode light source (52) that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through a fiber optic endoscope (60) to the tissue under observation. The system also includes a compact camera (100) for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors (102,104) by a fixed beamsplitter (106) in the camera. The fixed beamsplitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller (64) where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.
