Inhibiting CAV3 isoforms and the delta25B splice varients for the diagnosis and treatment of cancer

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专利权人:

University of Virginia Patent Foundation

发明人:

Gray, Lloyd S.,Macdonald, Timothy L.

申请号：

AU2012201933

公开号：

AU2012201933A1

申请日:

2012.04.03

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2012201933A120120426.pdf#####C:UNRownbDccAMCU737274.OC-Am7o2n ABSTRACT The invention provides a pharmaceutical composition comprising an antibody that specifically binds to a Cav3 isoform or its 825 splice variants thereof. The present 5 invention also relates to compositions and methods for inhibiting cancer cell proliferation, preventing, treating and/or controlling cancer and/or related disorders in a patient by administering to the patient a therapeutically effective amount of the T type calcium channel selective inhibitor. A preferred T type calcium channel selective inhibitor is mibefradil.

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