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SURFACTANT-FREE, WATER-FREE, FOAMABLE COMPOSITIONS AND BREAKABLE FOAMS AND THEIR USES
专利权人:
DOV TAMARKIN
发明人:
DOV TAMARKIN,ELANA GAZAL,IRAKLIY PAPIASHVILI,YOHAN HAZOT,DAVID SCHUZ,RIYA KEYNAN
申请号:
IL218866
公开号:
IL218866A
申请日:
2012.03.27
申请国别(地区):
IL
年份:
2012
代理人:
摘要:
A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents and the amount of viscosity modifying agents can optionally be reduced by at least an amount by weight that would have increased the viscosity of the carrier without the tetracycline antibiotic by at least 30% wherein the tetracycline is chemically stable in the composition for at least six months wherein more than about 90% of the tetracycline has not broken down wherein when packaged in an aerosol container to which is added a liquefied or compressed gas propellant the composition affords upon release from the container a breakable foam of at least good quality that breaks easily upon application of shear force.
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