Sara Nuñez Garcia;Michael Mlinaric;Konrad F. Koehler;Pieter Smid;Elmar Wegener;Josephus H. M. Lange
发明人:
Pieter Smid,Michael Mlinaric,Konrad F. Koehler,Sara Nuñez Garcia,Elmar Wegener,Josephus H. M. Lange
申请号：
US13133042
公开号：
US08575148B2
申请日:
2009.12.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention concerns spiro azepane-ox-azolidinones as voltage gated Kv1.3 potassium channel blockers, pharmaceutical compositions containing these compounds, methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in the treatment of diabetes, psoriasis, obesity, transplant rejection and inflammatory neuropathies, including T-cell mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. The compounds have formula (1):wherein R1, R2, (R3)n, and (R4)m have the meanings given in the specification.
