Mogam Institute for Biomedical Research;Green Cross Corporation
发明人:
KIM, So Ra,JUNG, Myung Eun,KIM, Min Jung,JO, Seung Hyun,HWANG, Sung Ho,KWAK, Hee Chun,LEE, Su Min,NAM, Hyun Ja
申请号：
AU2018341437
公开号：
AU2018341437A1
申请日:
2018.09.20
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates to a factor VIII or factor IX gene knockout rabbit, a method for preparing the same and a use thereof and, more particularly, to a transgenic rabbit whose factor VIII or factor IX gene has been knocked out through the CRISPR/Cas9 system, a method for preparing the same and a use thereof. According to the present invention, in the transgenic rabbit, whose factor VIII and/or factor IX gene has been knocked out, the functions of factor VIII and/or factor IX, which are proteins that perform critical functions for the development of hemophilia, are inhibited, such that the transgenic rabbit is useful for the development of hemophilia treatments.
