MILLER, JONATHAN,GOKHALE, RAJEEV,SCHMITT, ERIC A.,GAO, YI,LAFOUNTAINE, JUSTIN,DIAS, LLOYD
申请号：
PE0022852012
公开号：
PE02312013A1
申请日:
2011.06.07
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to a product in solid dispersion comprising: a) a compound of Kinase Inhibitor such as n - (4 - (4 - amino - 7 - [1 - (2-hydroxyethyl) - 1h-pyrazol-4-yl] thieno [3,2 - C] pyridin-3-yl) - phenyl) n - (3-fluorophenyl) urea, this 1% to 40% by Weight equivalent to the Free Base (b) an Acid as AC Gone, acetic acid, lactic acid, SUCCINIC ACID, among others, present among 0,1 to 10 equivalent with respect to the compound inhibitor kinase c) a polymeric vehicle as homopolymers and copolymers of N - Vinyl lactams, Cellulose esters, among others, present between 40% to 85% by weight and (d) a Surfactant of sorbitan monoesters as polysorbates, succinate, d And glycol, among others, present between 5% to 30% by weight. Also referred to a process of Preparation.This Compound is useful for the treatment of cancer.dci: ilorasertibSE REFIERE A UN PRODUCTO EN DISPERSION SOLIDA QUE COMPRENDE: A) UN COMPUESTO INHIBIDOR DE QUINASA TAL COMO N-(4-{4-AMINO-7-[1-(2-HIDROXIETIL)-1H-PIRAZOL-4-IL]TIENO[3,2-c]PIRIDIN-3-IL}FENIL)-N´-(3-FLUOROFENIL)UREA, PRESENTE ENTRE 1% A 40% EN PESO EQUIVALENTE A LA BASE LIBRE B) UN ACIDO TAL COMO ACIDO ACETICO, ACIDO LACTICO, ACIDO SUCCINICO, ENTRE OTROS, PRESENTE ENTRE 0,1 A 10 EQUIVALENTES CON RESPECTO AL COMPUESTO INHIBIDOR DE QUINASA C) UN VEHICULO POLIMERICO TAL COMO HOMOPOLIMEROS Y COPOLIMEROS DE N-VINIL LACTAMAS, ESTERES DE CELULOSA, ENTRE OTROS, PRESENTE ENTRE 40% A 85% EN PESO Y D) UN TENSIOACTIVO TAL COMO POLISORBATOS, MONOESTERES DE SORBITAN, SUCCINATO DE GLICOL, ENTRE OTROS, PRESENTE ENTRE 5% A 30% EN PESO. REFERIDO ADEMAS UN PROCESO DE PREPARACION. DICHO COMPUESTO ES UTIL PARA EL TRATAMIENTO DE CANCER.DCI: ILORASERTIB
