Andrea JAKABCINOVÁ;Csilla ULICNÁ;UNIVERZITA PAVLA JOZEFA SAFÁRIKA V KOSICIACH
发明人:
Andrea JAKABCINOVÁ,Csilla ULICNÁ,Marta PÚCATOVÁ,Patrik JAKABCIN,Jozef ULICNÝ
申请号：
US16339446
公开号：
US20200046855A1
申请日:
2017.10.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A contrast mixture with increased affinity and selectivity to neoplasms of the gastrointestinal tract, being of three components and consisting of 0.0005-0.01% by weight of low-molecular component, 0.05-6% by weight of high-molecular component and isotonic solution, wherein low-molecular component is a contrast substance, which is a colouring agent used in food industry and pharmacy and high-molecular component is a colloid modulator of velocity designed to decelerate diffusion of the contrast mixture into a tissue in such manner that the velocity of diffusion into healthy tissue of gastrointestinal tract and the velocity of diffusion into neoplasm tissue of gastrointestinal tract is different. In an embodiment, the colouring agent is the sodium and/or calcium salt of [4-(alpha-(4-diethylaminophenyl)-5-hydroxy-2,4-disulphophenylmethylidene)-2,5-cyclohexadiene-1-ylidene] diethylammonium hydroxide or 3,7-bis(Dimethylamino)-phenothia zin-5-ium chloride and the colloid modulator of velocity is a starch, pectin, agar-agar (agarose and agaropectins) and/or non-linearly branched amylopectins. A use of the contrast mixture for colour sharp distinction of the interface between healthy tissue and neoplasm tissue of gastrointestinal tract.
