method for modulating hepatitis b cccdna transcription in an individual, method for modulating covalently closed circular hepatitis b virus dna and compound农业专利-农业学术服务平台

专利权人:: BARUCH S. BLUMBERG INSTITUTE;BARUCH S. BLUMBERG INSTITUTE;DREXEL UNIVERSITY;DREXEL UNIVERSITY

发明人:: HAROLD R. ALMOND,HAROLD R. ALMOND,JINHONG CHANG,JINHONG CHANG,JU-TAO GUO,JU-TAO GUO,TIMOTHY M. BLOCK,TIMOTHY M. BLOCK,WILLIAM A. KINNEY,WILLIAM A. KINNEY

摘要：: The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in the management of chronic HBV. The compounds of the invention achieve epigenetic modification of the cccDNA, histone modification and histone deacetylase activity inhibition, thus modulating HBV cccDNA. The present invention further provides methods for modulating HBV cccDNA, for treating or preventing HBV in a subject, and for modulating cccDNA transcription of hepatitis B in a subject.