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novel piperazines, pharmaceutical compositions and methods of use thereof
专利权人:
CORNERSTONE THERAPEUTICS INC.
发明人:
CLARK, ROGER B.,ELBAUM, DANIEL
申请号:
ES07809388
公开号:
ES2498043T3
申请日:
2007.06.06
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of Formula (III): ** Formula ** or a pharmaceutically acceptable salt thereof where: R1 is selected from the group consisting of H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3 cycloalkyl -C10, C4-C10 cycloalkenyl, -C (O) R5, C (O) OR5 and C (O) NR5R5; V is selected from the group consisting of a link, C (R4) 2, C (R4) C (R4) 2, C (R4) 2C (R4) 2R6, C (R4) 2C (R4) 2C (R4) 2R6, CO, -C (O) R6, C (S), C (S) R6, CH2C (O), CH2C (O) R6, CH2C (S), CH2C (S) R6, SO2 and SO2R6; A is a linking group -C (Ra) 2-Xa-, Xa is selected from the group consisting of O, C (R4) 2O, OC (R4) 2, NR5, CO, C (R4) 2CO, CONR5 , C (R4) 2NR5, NR5C (R4) 2, NR5C (O), NR5C (O) C (R4) 2, S, C (R4) 2S and SC (R4) 2.Un compuesto de Fórmula (III):**Fórmula** o una de sus sales farmacéuticamente aceptables donde: R1 se selecciona entre el grupo que consiste en H, alquilo C1-C10, alquenilo C2-C10, alquinilo C2-C10, cicloalquilo C3-C10, cicloalquenilo C4-C10, -C(O)R5, C(O)OR5 y C(O)NR5R5; V se selecciona entre el grupo que consiste en un enlace, C(R4)2, C(R4)C(R4)2, C(R4)2C(R4)2R6, C(R4)2C(R4)2C(R4)2R6, CO, -C(O)R6, C(S), C(S)R6, CH2C(O), CH2C(O)R6, CH2C(S), CH2C(S)R6, SO2 y SO2R6; A es un grupo de unión -C(Ra)2-Xa-, Xa se selecciona entre el grupo que consiste en O, C(R4)2O, OC(R4)2, NR5, CO, C(R4)2CO, CONR5, C(R4)2NR5, NR5C(R4)2, NR5C(O), NR5C(O)C(R4)2, S, C(R4)2S y SC(R4)2.
来源网站:
中国工程科技知识中心
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