Samuel Davis,Eric Smith,Douglas MacDonald,Kara Louise Olson
申请号：
US15058026
公开号：
US09982013B2
申请日:
2016.03.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.
