The present invention relates to preparation method of drugs and intermediate compounds thereof, in particular, to preparation method of entecavir, intermediate compounds thereof and synthetic method of said intermediate compounds.本發明涉及藥物的製備方法及其中間體化合物,具體而言,涉及恩替卡韋的製備方法、其中間體化合物以及所述中間體化合物的合成方法。