THOMAS THUM,JOHANN BAUERSACHS,STEFAN ENGELHARDT,CARINA GROSS
申请号：
PT09714079
公开号：
PT2260101E
申请日:
2009.02.26
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
The present invention relates to a promoter region of a microRNA, the use of a microRNA, in particular miR-21, and related elements for the diagnosis and for the manufacture of a medicament for the treatment and/or prevention of fibrosis and/or fibrosis related diseases. Additionally, the invention concerns antisense oligonucleotides against targets of miR-21. A cell deficient for miR-21, the promoter region and targets of miR-21 and a knock-out organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases.
