Ping Zhang;Xinting Chen;Juan Zhang;Haichun Zhang;Caixia Su;Guixing Li;Xiaoyu Li
发明人:
Guixing Li,Ping Zhang,Haichun Zhang,Xinting Chen,Xiaoyu Li,Juan Zhang,Caixia Su
申请号：
US14117937
公开号：
US20140112954A1
申请日:
2012.04.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention discloses a method for preparing HBV Vaccine comprising aluminum adjuvant, which belongs to biological technology field. The method, which is characterized in that aluminum adjuvant Al(OH)3 is produced by an on-line reaction, comprises mixing PBS buffer solution and potassium aluminum sulfate (KAl(SO4)2) solution with hepatitis B surface antigen stock solution, adding sodium hydroxide (NaOH) solution into the mixed solution, so that the adjuvant is continuously produced and hepatitis B surface antigens are continuously coated and absorbed simultaneously. The process is called “in-situ adsorption”.
