GEORGE HYND,YANN GRIFFON,DAVID MIDDLEMISS,NICHOLAS CHARLES RAY,HARRY FINCH,JOHN GARY MONTANA,MICHAEL COLIN CRAMP,TREVOR KEITH HARRISON,ROSA ARIENZO,PAUL BLANEY
申请号：
BRPI0721477
公开号：
BRPI0721477A2
申请日:
2007.03.21
申请国别(地区):
BR
年份:
2013
代理人:
摘要：
INDOLIZIN ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS. Specific compounds on this list: {7-cyano-2-methyl-1- [4- (morpholin-4-sulfonyl] indolizin-3-yl} acetic acid, [1- (3-chloro-4-ethanesulfonylbenzyl) - 7-cyano-2-methylindolizin-3-yl] acetic acid {1- [3-chloro-4- (morpholin-4-sulfonyl) benzyl] -7-cyano-2-methylindolizin-3-yl} acetic acid [1- (3-Chloro-4-ethanesulfonylphenylsulfanyl) -7-cyano-2-methylindolizin-3-yl] acetic acid {1- [3-chloro-4- (morpholin-4-sulfonyl} phenylsulfanyl] -7- cyano-2-methylindolizin-3-yl} acetic acid [7-cyano-1- (6-fluoroquinolin-2-ylmethyl) -2-methylindolizin-3-yl] acetic acid are CRTH2 receptor ligands and are useful in the treatment of respiratory diseases.DERIVADOS DE ÁCIDO INDOLIZINA ACÉTICO COMO ANTAGONISTAS DE CRTH2. Os compostos específicos dessa lista: ácido {7-ciano-2-metil-1- [4-(morfolina-4-sulfonil] indolizin-3-il}acético, ácido [1-(3-cloro-4-etanossulfonilbenzil)-7-ciano- 2-metilindolizin-3-il] acético, ácido{1- [3-cloro-4-(morfolina-4-sulfonil) benzil]-7-ciano-2-metilindolizin-3-il} acético, ácido [1- (3-cloro-4-etanossulfonilfenilsulfanil)-7-ciano-2-metilindolizin-3-il] acético, ácido {l- [3-cloro-4- (morfolina-4-sulfonil} fenilsulfanil]-7-ciano-2-metilindolizin-3-il} acético, ácido [7-ciano-l-(6- fluoroquinolin-2-ilmetil) -2-metilindolizin-3-il] acético são ligandos do receptor CRTH2 e são úteis no tratamento de doenças respiratórias.
