The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.本發明係有關於嘌呤酮衍生物,其係HM74a受體之同效劑。進一步提供使用此間之化合物之組成物及方法,及其用於治療疾病之藥學可接受鹽。