The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a saltthereof, or a solvate of the derivative or the salt: wherein Xand Y each independently represent a direct bond, NH, CH=CH, O,or S； R1 and R2 each independently represent a hydrogen atom, ahalogen atom, a cyano group, an alkyl group, or the like； R3and R4 each independently represent a hydrogen atom, an alkylgroup, or the like, or R3 and R4 together form an alkylenegroup or an alkenylene group, which may be bridged between twocarbon atoms to an arbitrary position； and l, m, and nrepresent an integer number of 1 to 4.(see formula 1)
