PROBLEM TO BE SOLVED: To provide an easily-acceptable pharmaceutical composition containing an opioid and an opioid antagonist, especially a composition of an opioid antagonist applicable even to the case of opioid addict or opioid resistance.SOLUTION: This invention relates to a pharmaceutical composition, comprising at least one particle containing at least one kind of opioid or a pharmaceutically acceptable salt thereof, and at least one kind of opioid antagonist or a pharmaceutically acceptable salt thereof, wherein the release of the opioid antagonist takes place continuously over a time period of 30 minutes up to 8 hours after oral administration.COPYRIGHT: (C)2012,JPO&INPIT【課題】オピオイドおよびオピオイド拮抗薬を含む、さらに容易に許容される医薬組成物、特に、オピオイド依存症またはオピオイド耐性の場合にも適用可能なオピオイド拮抗薬の組成物の提供。【解決手段】少なくとも1種類のオピオイドまたはそれらの薬学的に許容できる塩と、少なくとも1種類のオピオイド拮抗薬またはそれらの薬学的に許容できる塩とを含む、少なくとも1つの粒子を含み、経口投与後、前記オピオイド拮抗薬の放出が30分~8時間にわたり継続的に生じる医薬組成物。【選択図】図1
