The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet； and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet； wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide； and form a discontinuous phase within the matrix material； and method of using said tablet to treat pain and other conditions.
