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EXTENDED RELEASE PHARMACEUTICAL SOLID DOSAGE FORMULATIONS
专利权人:
MYLAN INC.
发明人:
John David KIRSCH,Chaoju XIAO
申请号:
US14775221
公开号:
US20160022591A1
申请日:
2014.03.13
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A solid pharmaceutical dosage form, e.g., a tablet, is disclosed which comprises (a) a sustained released matrix core containing i) an at least sparingly water soluble active pharmaceutical ingredient, ii) a hydrophilic polymer, iii) an optional hydrophobic polymer, iv) an optional wax component, and v) optional diluent; and (b) a semi-permeable functional film coating surrounding the core, wherein the dosage form is substantially resistant to dose dumping when administered in the presence of ethanol. A method for making the dosage form is also provided in which the dosage form is coated with a semi-permeable coating.
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