HESLIN, DAVID,ALLY, ROXANNE,SIAO, CHIA-JEN,LAI, KA-MAN VENUS,VALENZUELA, DAVID M.,GUO, CHUNGUANG,LACROIX-FRALISH, MICHAEL,MACDONALD, LYNN,SHARMA, AARTI,KAJIMURA, DAISUKE,DROGUETT, GUSTAVO,FRENDEWEY, D
申请号：
CA3038548
公开号：
CA3038548A1
申请日:
2017.09.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
For disease associated with the hexanucleotide of a C9ORF72 xenogenesis an inhuman animal (such as, one rodent) model repeats to provide expansion order, inhuman animal include an xenogenesis hexanucleotide in one at the places C9ORF72 in repeat (GGGGCC). The inhuman animal reexpansion sequence disclosed herein of one of hexanucleotide including an xenogenesis its include at least: an example, such as it repeats, one hexanucleotide (GGGGCC) sequence can further show a distinctive and/or phenotype, it is associated with one or more neurodegenerative disorders (for example, amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD) etc.). The method for identifying the therapeutic candidate that can be used for preventing, is postponed or processing one or more neurodegenerative (for example, amyotrophic lateral sclerosis (ALS, also referred to as Lou Gehrig disease) and frontotemporal dementias (FTD)) is also provided.
