Chemical compounds are transmitted as selective target countries of N2b receptor. In addition, drug components containing these compounds, as well as treatment methods for various diseases and disorders related to NR2B resistance, such as diseases and disorders of the national unified classification system of chemicals, are also transmitted, Claim 1: a chemical entity, a formula compound (1),where: R¹ is alkyl, cycloalkyl, (cycloalkyl) alkyl, heterocyclyl, (heterocyclyl) alkyl, aryl, (aryl) alkyl, heteroaryl or (heteroaryl) alkyl, where each of cycloalkyl, (cycloalkyl) alkyl, heterocyclyl, (heterocyclyl) alkyl, aryl, (aryl) alkyl, heteroaryl and (heteroaryl) alkyl is,independently, optionally substituted with 1 to 3 groups independently selected from -F, -Cl, C₁₋₄ alkyl, cyclopropyl, -C ° CH, -CFH₂,-CF₂H, -CF₃,-CF₂CH₃,-CH₂CF₃,C₁₋₄ alkoxy, -OCFH₂,-OCF₂H, -OCF₃,-CN -N (R) (R)-No.8322；C₁₋₄ alkylthio, C₁₋₄ alkylsulfonyl and -S (O) ₂CF₃；where each case of R² and R³ is independently -H or C₁₋₄ alkyl, or -N (R²) (R³) is a residue selected from the group of formulas (2)；Z is a heteromorphic atom composed of 5 to 6 single period atoms or 9 to 10 single period atoms selected independently of N, O and s, including cyclic carbon atom, 1 nitrogen cyclic atom and 0-3 extra heteromorphic cyclic atoms, Alternative 1 or 2 r739 groups replaced, alternative 1 r74919 group replaced；a. Each r739 is combined with the ring carbon atom, and r74919 is combined with the ring nitrogen atom；-CFH₂,-CF₂H, -CF₃,-Oh, oc832323,-OCF₃ or -CN； and Rᵃ is C₁₋₄ alkyl, C₃₋₄ cycloalkyl or -S (O) ₂-C₁₋₄ alkyl.Se divulgan compuestos químicos como antagonistas selectivos de receptor subtipo NR2B. Además, se divulgan composiciones farmacéuticas que comprenden dichos compuestos, y métodos de tratamiento de diversas enfermedades y trastornos asociados con el antagonismo de NR2B, por ejemplo, enfermedades y trastornos del SNC, tales como depresión. Reivindicación 1: Una entidad química, que es un compuesto de la
