<;P>;PROBLEM TO BE SOLVED: To obtain a new pharmaceutical composition on the basis of knowledge acquired by elucidating the function of MOCA in nerve cells and to provide a method for screening a new therapeutic agent. <;P>;SOLUTION: The pharmaceutical composition comprises MOCA (Modifier of cell adhesion protein), its pharmacologically acceptable salt or its hydrate as an active ingredient. <;P>;COPYRIGHT: (C)2008,JPO&INPIT