FELDMAN DAVID LOUIS,펠드맨, 데이비드, 루이스,WEBB RANDY LEE,웹, 랜디, 리
申请号：
KR1020137023159
公开号：
KR1020130109244A
申请日:
2003.05.16
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The invention relates to a pharmaceutical composition comprising (i) a renin inhibitor, (ii) a calcium channel blocker (CCB), and (iii) a diuretic and to a method of treatment of a condition or a disease selected from the group consisting of hypertension, heart failure such as (acute and chronic) congestive heart failure, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiac myopathy, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, atherosclerosis, angina (whether unstable or stable), renal insufficiency (diabetic and non- diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis (including IgA nephropathy), renal fibrosis, scleroderma, glomerular sclerosis, proteinuria of renal disease, and also renal vascular hypertension, diabetic retinopathy, the management of other vascular disorders, such as migraine, peripheral vascular disease, Raynaud's disease, luminal hyperplasia, cognitive dysfunction (such as Alzheimer's), glaucoma and stroke, pulmonary and hepatic fibrosis, fibrotic diseases resulting from accumulation of excess extracellular matrix induced by TGF, and proliferative diseases of smooth muscle cells, including uterine fibroids comprising administering a therapeutically effective amount of said pharmaceutical composition to a mammal in need of such treatment.본 발명은 (i) 레닌 억제제, (ii) 칼슘 채널 차단제 (CCB), 및 (iii) 이뇨제를 함유하는 약제학적 조성물, 및 상기의 약제학적 조성물의 치료학적 유효량을 치료가 필요한 포유동물에게 투여하는 것을 포함하는, 고혈압, 심부전증, 예를 들어 (급성 및 만성) 울혈성 심부전증, 좌심실기능장애 및 비후성 심근병증, 당뇨병성 심장근육병증, 상심실성 및 심실성 부정맥, 심방세동, 심방조동, 유해한 혈관 리모델링, 심근경색 및 그의 후유증, 아테롬성동맥경화증, 협심증 (안정성이든 불안정성이든), 신부전증 (당뇨병성 및 비-당뇨병성), 심부전증, 협심증, 당뇨병, 속발성 알도스테론증, 원발성 및 속발성 폐고혈압, 신부전 상태, 예를 들어 당뇨병성 신장병증, 사구체신염 (IgA 신장병증을 포함), 신섬유증, 공피증, 사구체 경화증, 신장질환의 단백뇨, 신혈관 고혈압, 및 당
