Method for topical protection, advantageously on the skin and / or mucous membrane and / or integuments, against atmospheric polluting molecules and ultraviolet (UV) radiation, comprising the steps of: a) forming on the skin and / or mucous membranes and / or integuments a repellent and anti-adhesive polymer matrix with respect to atmospheric polluting molecules, by means of a first biocompatible polymer (PB1)； b) degrading by photocatalysis under the effect of UV radiation the polluting molecules having penetrated into the polymer matrix by means of first colloid semiconductors grafted (Col-1) covalently with a second biocompatible polymer (PB2) different from the first polymer biocompatible (PB1), resulting in fact in the formation of free radicals； c) neutralize said free radicals by means of at least 2 antioxidants respectively: - a first antioxidant in the form of second semiconductor colloids (Col-2) grafted covanlent with said first antioxidant (AntiOx-1)； the second grafted colloids (Col-2) self-regenerating under the action of UV radiation by the following mechanism: • regeneration of the first antioxidant AntiOx-1) by electron transfer from the second colloids (Col-2) to said first antioxidant (AntiOx-1), • regeneration of second colloids (Col-2) by exposure to UV radiation, - a second antioxidant agent (AntiOx-2) not in the form of colloids grafted with an antioxidant； d) stabilize the polymer matrix by means of the second antioxidant agent (AntiOx-2). Procédé de protection topique, avantageusement sur la peau et/ou muqueuse et/ou phanères, vis-à-vis des molécules polluantes atmosphériques et du rayonnement ultraviolet (UV), comprenant les étapes de : a) former sur la peau et/ou les muqueuses et/ou les phanères une matrice polymérique répulsive et anti-adhésive vis-à-vis des molécules polluantes atmosphériques, au moyen d'un premier polymère biocompatible (PB1) ； b) dégrader par photocatalyse sous l'effet du rayonnement UV les molécules pol
