A pharmaceutical composition comprising: (A) at least one compound of formula (I): wherein X is O or S, preferably O R6 is H, C1-6alkyl, -(CH2)pCOOH, -(CH2)pCOOC1-6alkyl, -(CH2)pCONH2, - (CH2)pCONHC1-6alkyl, -(CH2)pCON(C1-6alkyl)2, R11 is H or C1-6 alkyl； each R5 is -OC1-10alkyl, -SC1-10alkyl, -C1-12alkyl, or OAr2； wherein Ar2 is phenyl, optionally substituted with one or more halo； each p is 0 to 3； each z is 1 to 2； or a pharmaceutically acceptable salt, or a hydrate or solvate thereof； and (B) one or more corticosteroid partners, preferably selected from the group consisting of betamethasone, clobetasol, halometasone, dexamethasone, fluocortolone, desoximetasone, diflorasone, fluocinonide, flurandrenolide, halobetasol, amcinonide, halocinonide, triamcinolone, hydrocortisone, aclometasone, fluticasone, mometasone, clocortolone, fluocinolone, desonide, prednisone, prednisolone,and prednicarbate or a pharmaceutically acceptable salt, or a hydrate or solvate thereof, especially betamethasone or a pharmaceutically acceptable salt, or a hydrate or solvate thereof.
