Terence Seward Baker,Michael Anthony William Eaton,Timothy John Norman,James Petrie Turner
申请号：
US16337243
公开号：
US20190298859A1
申请日:
2017.09.27
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compounds of formula (I), wherein Ar is an aryl group optionally further substituted with one or more groups R3； A is a lipophilic, hydrophobic moiety； R1 is a phosphodiester, phosphotriester, thioether or amide group； X is an unsubstituted or substituted C6 to C24 alkylene or alkenylene group, which is optionally interrupted by one or more —；NR9—；, —；O—； or —；S—； linkages, R2 is —；YC(R4)(R5)CO2R6； and pharmaceutically acceptable salts or solvates thereof are useful as endosomolytic agents particularly for the delivery of nucleic acids useful in gene therapy.
